The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Identifieur interne : 000841 ( Main/Exploration ); précédent : 000840; suivant : 000842The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Auteurs : Parvaneh Mehrbod [Iran] ; Sudharsana R. Ande [Canada] ; Javad Alizadeh [Canada] ; Shahrzad Rahimizadeh [Canada] ; Aryana Shariati [Canada] ; Hadis Malek [Iran] ; Mohammad Hashemi [Iran] ; Kathleen K M. Glover [Canada] ; Affan A. Sher [Canada] ; Kevin M. Coombs [Canada] ; Saeid Ghavami [Canada]Source :
- Virulence [ 2150-5608 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Arbovirus (génétique), Arbovirus (métabolisme), Autophagie, Humains, Orthomyxoviridae (génétique), Orthomyxoviridae (métabolisme), Protéines régulatrices de l'apoptose, Réponse aux protéines mal repliées, Souris, Stress physiologique, Transduction du signal, VIH (Virus de l'Immunodéficience Humaine) (génétique), VIH (Virus de l'Immunodéficience Humaine) (métabolisme).
- MESH :
- génétique : Arbovirus, Orthomyxoviridae, VIH (Virus de l'Immunodéficience Humaine).
- métabolisme : Arbovirus, Orthomyxoviridae, VIH (Virus de l'Immunodéficience Humaine).
- Animaux, Apoptose, Autophagie, Humains, Protéines régulatrices de l'apoptose, Réponse aux protéines mal repliées, Souris, Stress physiologique, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Apoptosis, Apoptosis Regulatory Proteins, Arboviruses (genetics), Arboviruses (metabolism), Autophagy, HIV (genetics), HIV (metabolism), Host Microbial Interactions, Humans, Mice, Orthomyxoviridae (genetics), Orthomyxoviridae (metabolism), Signal Transduction, Stress, Physiological, Unfolded Protein Response.
- MESH :
- chemical : Apoptosis Regulatory Proteins.
- genetics : Arboviruses, HIV, Orthomyxoviridae.
- metabolism : Arboviruses, HIV, Orthomyxoviridae.
- Animals, Apoptosis, Autophagy, Host Microbial Interactions, Humans, Mice, Signal Transduction, Stress, Physiological, Unfolded Protein Response.
Abstract
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR). Both autophagy and UPR are connected to programed cell death I (apoptosis) in chronic stress conditions to regulate cellular homeostasis via Bcl2 family proteins, CHOP and Beclin-1. In this review article we first briefly discuss arboviruses, influenza virus, and HIV and then describe the concepts of apoptosis, autophagy, and UPR. Finally, we focus upon how apoptosis, autophagy, and UPR are involved in the regulation of cellular responses to arboviruses, influenza virus and HIV infections. Abbreviation: AIDS: Acquired Immunodeficiency Syndrome; ATF6: Activating Transcription Factor 6; ATG6: Autophagy-specific Gene 6; BAG3: BCL Associated Athanogene 3; Bak: BCL-2-Anatagonist/Killer1; Bax; BCL-2: Associated X protein; Bcl-2: B cell Lymphoma 2x; BiP: Chaperon immunoglobulin heavy chain binding Protein; CARD: Caspase Recruitment Domain; cART: combination Antiretroviral Therapy; CCR5: C-C Chemokine Receptor type 5; CD4: Cluster of Differentiation 4; CHOP: C/EBP homologous protein; CXCR4: C-X-C Chemokine Receptor Type 4; Cyto c: Cytochrome C; DCs: Dendritic Cells; EDEM1: ER-degradation enhancing-a-mannosidase-like protein 1; ENV: Envelope; ER: Endoplasmic Reticulum; FasR: Fas Receptor;G2: Gap 2; G2/M: Gap2/Mitosis; GFAP: Glial Fibrillary Acidic Protein; GP120: Glycoprotein120; GP41: Glycoprotein41; HAND: HIV Associated Neurodegenerative Disease; HEK: Human Embryonic Kidney; HeLa: Human Cervical Epithelial Carcinoma; HIV: Human Immunodeficiency Virus; IPS-1: IFN-β promoter stimulator 1; IRE-1: Inositol Requiring Enzyme 1; IRGM: Immunity Related GTPase Family M protein; LAMP2A: Lysosome Associated Membrane Protein 2A; LC3: Microtubule Associated Light Chain 3; MDA5: Melanoma Differentiation Associated gene 5; MEF: Mouse Embryonic Fibroblast; MMP: Mitochondrial Membrane Permeabilization; Nef: Negative Regulatory Factor; OASIS: Old Astrocyte Specifically Induced Substrate; PAMP: Pathogen-Associated Molecular Pattern; PERK: Pancreatic Endoplasmic Reticulum Kinase; PRR: Pattern Recognition Receptor; Puma: P53 Upregulated Modulator of Apoptosis; RIG-I: Retinoic acid-Inducible Gene-I; Tat: Transactivator Protein of HIV; TLR: Toll-like receptor; ULK1: Unc51 Like Autophagy Activating Kinase 1; UPR: Unfolded Protein Response; Vpr: Viral Protein Regulatory; XBP1: X-Box Binding Protein 1.
DOI: 10.1080/21505594.2019.1605803
PubMed: 30966844
Affiliations:
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Glover</name><affiliation wicri:level="1"><nlm:affiliation>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Sher, Affan A" sort="Sher, Affan A" uniqKey="Sher A" first="Affan A" last="Sher">Affan A. Sher</name><affiliation wicri:level="1"><nlm:affiliation>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Coombs, Kevin M" sort="Coombs, Kevin M" uniqKey="Coombs K" first="Kevin M" last="Coombs">Kevin M. Coombs</name><affiliation wicri:level="1"><nlm:affiliation>d Children's Hospital Research Institute of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>d Children's Hospital Research Institute of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30966844</idno><idno type="pmid">30966844</idno><idno type="doi">10.1080/21505594.2019.1605803</idno><idno type="wicri:Area/PubMed/Corpus">000213</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000213</idno><idno type="wicri:Area/PubMed/Curation">000213</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000213</idno><idno type="wicri:Area/PubMed/Checkpoint">000172</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000172</idno><idno type="wicri:Area/Ncbi/Merge">000A07</idno><idno type="wicri:Area/Ncbi/Curation">000A07</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A07</idno><idno type="wicri:Area/Main/Merge">000842</idno><idno type="wicri:Area/Main/Curation">000841</idno><idno type="wicri:Area/Main/Exploration">000841</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.</title><author><name sortKey="Mehrbod, Parvaneh" sort="Mehrbod, Parvaneh" uniqKey="Mehrbod P" first="Parvaneh" last="Mehrbod">Parvaneh Mehrbod</name><affiliation wicri:level="1"><nlm:affiliation>a Influenza and Respiratory Viruses Department , Past eur Institute of IRAN , Tehran , Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>a Influenza and Respiratory Viruses Department , Past eur Institute of IRAN , Tehran </wicri:regionArea><wicri:noRegion>Tehran </wicri:noRegion></affiliation></author><author><name sortKey="Ande, Sudharsana R" sort="Ande, Sudharsana R" uniqKey="Ande S" first="Sudharsana R" last="Ande">Sudharsana R. Ande</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Internal Medicine , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>b Department of Internal Medicine , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Alizadeh, Javad" sort="Alizadeh, Javad" uniqKey="Alizadeh J" first="Javad" last="Alizadeh">Javad Alizadeh</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Rahimizadeh, Shahrzad" sort="Rahimizadeh, Shahrzad" uniqKey="Rahimizadeh S" first="Shahrzad" last="Rahimizadeh">Shahrzad Rahimizadeh</name><affiliation wicri:level="1"><nlm:affiliation>f Department of Medical Microbiology , Assiniboine Community College, School of Health and Human Services and Continuing Education , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>f Department of Medical Microbiology , Assiniboine Community College, School of Health and Human Services and Continuing Education , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Shariati, Aryana" sort="Shariati, Aryana" uniqKey="Shariati A" first="Aryana" last="Shariati">Aryana Shariati</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Malek, Hadis" sort="Malek, Hadis" uniqKey="Malek H" first="Hadis" last="Malek">Hadis Malek</name><affiliation wicri:level="1"><nlm:affiliation>g Department of Biology , Islamic Azad University , Mashhad , Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>g Department of Biology , Islamic Azad University , Mashhad </wicri:regionArea><wicri:noRegion>Mashhad </wicri:noRegion></affiliation></author><author><name sortKey="Hashemi, Mohammad" sort="Hashemi, Mohammad" uniqKey="Hashemi M" first="Mohammad" last="Hashemi">Mohammad Hashemi</name><affiliation wicri:level="1"><nlm:affiliation>h Department of Clinical Biochemistry , Zahedan University of Medical Sciences , Zahedan , Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>h Department of Clinical Biochemistry , Zahedan University of Medical Sciences , Zahedan </wicri:regionArea><wicri:noRegion>Zahedan </wicri:noRegion></affiliation></author><author><name sortKey="Glover, Kathleen K M" sort="Glover, Kathleen K M" uniqKey="Glover K" first="Kathleen K M" last="Glover">Kathleen K M. Glover</name><affiliation wicri:level="1"><nlm:affiliation>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Sher, Affan A" sort="Sher, Affan A" uniqKey="Sher A" first="Affan A" last="Sher">Affan A. Sher</name><affiliation wicri:level="1"><nlm:affiliation>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>i Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Coombs, Kevin M" sort="Coombs, Kevin M" uniqKey="Coombs K" first="Kevin M" last="Coombs">Kevin M. Coombs</name><affiliation wicri:level="1"><nlm:affiliation>d Children's Hospital Research Institute of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>d Children's Hospital Research Institute of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author><author><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>c Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB </wicri:regionArea><wicri:noRegion>MB </wicri:noRegion></affiliation></author></analytic><series><title level="j">Virulence</title><idno type="eISSN">2150-5608</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Apoptosis Regulatory Proteins</term><term>Arboviruses (genetics)</term><term>Arboviruses (metabolism)</term><term>Autophagy</term><term>HIV (genetics)</term><term>HIV (metabolism)</term><term>Host Microbial Interactions</term><term>Humans</term><term>Mice</term><term>Orthomyxoviridae (genetics)</term><term>Orthomyxoviridae (metabolism)</term><term>Signal Transduction</term><term>Stress, Physiological</term><term>Unfolded Protein Response</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Arbovirus (génétique)</term><term>Arbovirus (métabolisme)</term><term>Autophagie</term><term>Humains</term><term>Orthomyxoviridae (génétique)</term><term>Orthomyxoviridae (métabolisme)</term><term>Protéines régulatrices de l'apoptose</term><term>Réponse aux protéines mal repliées</term><term>Souris</term><term>Stress physiologique</term><term>Transduction du signal</term><term>VIH (Virus de l'Immunodéficience Humaine) (génétique)</term><term>VIH (Virus de l'Immunodéficience Humaine) (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Apoptosis Regulatory Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arboviruses</term><term>HIV</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Arbovirus</term><term>Orthomyxoviridae</term><term>VIH (Virus de l'Immunodéficience Humaine)</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Arboviruses</term><term>HIV</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Arbovirus</term><term>Orthomyxoviridae</term><term>VIH (Virus de l'Immunodéficience Humaine)</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Autophagy</term><term>Host Microbial Interactions</term><term>Humans</term><term>Mice</term><term>Signal Transduction</term><term>Stress, Physiological</term><term>Unfolded Protein Response</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Autophagie</term><term>Humains</term><term>Protéines régulatrices de l'apoptose</term><term>Réponse aux protéines mal repliées</term><term>Souris</term><term>Stress physiologique</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR). Both autophagy and UPR are connected to programed cell death I (apoptosis) in chronic stress conditions to regulate cellular homeostasis via Bcl2 family proteins, CHOP and Beclin-1. In this review article we first briefly discuss arboviruses, influenza virus, and HIV and then describe the concepts of apoptosis, autophagy, and UPR. Finally, we focus upon how apoptosis, autophagy, and UPR are involved in the regulation of cellular responses to arboviruses, influenza virus and HIV infections. Abbreviation: AIDS: Acquired Immunodeficiency Syndrome; ATF6: Activating Transcription Factor 6; ATG6: Autophagy-specific Gene 6; BAG3: BCL Associated Athanogene 3; Bak: BCL-2-Anatagonist/Killer1; Bax; BCL-2: Associated X protein; Bcl-2: B cell Lymphoma 2x; BiP: Chaperon immunoglobulin heavy chain binding Protein; CARD: Caspase Recruitment Domain; cART: combination Antiretroviral Therapy; CCR5: C-C Chemokine Receptor type 5; CD4: Cluster of Differentiation 4; CHOP: C/EBP homologous protein; CXCR4: C-X-C Chemokine Receptor Type 4; Cyto c: Cytochrome C; DCs: Dendritic Cells; EDEM1: ER-degradation enhancing-a-mannosidase-like protein 1; ENV: Envelope; ER: Endoplasmic Reticulum; FasR: Fas Receptor;G2: Gap 2; G2/M: Gap2/Mitosis; GFAP: Glial Fibrillary Acidic Protein; GP120: Glycoprotein120; GP41: Glycoprotein41; HAND: HIV Associated Neurodegenerative Disease; HEK: Human Embryonic Kidney; HeLa: Human Cervical Epithelial Carcinoma; HIV: Human Immunodeficiency Virus; IPS-1: IFN-β promoter stimulator 1; IRE-1: Inositol Requiring Enzyme 1; IRGM: Immunity Related GTPase Family M protein; LAMP2A: Lysosome Associated Membrane Protein 2A; LC3: Microtubule Associated Light Chain 3; MDA5: Melanoma Differentiation Associated gene 5; MEF: Mouse Embryonic Fibroblast; MMP: Mitochondrial Membrane Permeabilization; Nef: Negative Regulatory Factor; OASIS: Old Astrocyte Specifically Induced Substrate; PAMP: Pathogen-Associated Molecular Pattern; PERK: Pancreatic Endoplasmic Reticulum Kinase; PRR: Pattern Recognition Receptor; Puma: P53 Upregulated Modulator of Apoptosis; RIG-I: Retinoic acid-Inducible Gene-I; Tat: Transactivator Protein of HIV; TLR: Toll-like receptor; ULK1: Unc51 Like Autophagy Activating Kinase 1; UPR: Unfolded Protein Response; Vpr: Viral Protein Regulatory; XBP1: X-Box Binding Protein 1.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Mehrbod, Parvaneh" sort="Mehrbod, Parvaneh" uniqKey="Mehrbod P" first="Parvaneh" last="Mehrbod">Parvaneh Mehrbod</name></noRegion><name sortKey="Hashemi, Mohammad" sort="Hashemi, Mohammad" uniqKey="Hashemi M" first="Mohammad" last="Hashemi">Mohammad Hashemi</name><name sortKey="Malek, Hadis" sort="Malek, Hadis" uniqKey="Malek H" first="Hadis" last="Malek">Hadis Malek</name></country><country name="Canada"><noRegion><name sortKey="Ande, Sudharsana R" sort="Ande, Sudharsana R" uniqKey="Ande S" first="Sudharsana R" last="Ande">Sudharsana R. Ande</name></noRegion><name sortKey="Alizadeh, Javad" sort="Alizadeh, Javad" uniqKey="Alizadeh J" first="Javad" last="Alizadeh">Javad Alizadeh</name><name sortKey="Coombs, Kevin M" sort="Coombs, Kevin M" uniqKey="Coombs K" first="Kevin M" last="Coombs">Kevin M. Coombs</name><name sortKey="Ghavami, Saeid" sort="Ghavami, Saeid" uniqKey="Ghavami S" first="Saeid" last="Ghavami">Saeid Ghavami</name><name sortKey="Glover, Kathleen K M" sort="Glover, Kathleen K M" uniqKey="Glover K" first="Kathleen K M" last="Glover">Kathleen K M. Glover</name><name sortKey="Rahimizadeh, Shahrzad" sort="Rahimizadeh, Shahrzad" uniqKey="Rahimizadeh S" first="Shahrzad" last="Rahimizadeh">Shahrzad Rahimizadeh</name><name sortKey="Shariati, Aryana" sort="Shariati, Aryana" uniqKey="Shariati A" first="Aryana" last="Shariati">Aryana Shariati</name><name sortKey="Sher, Affan A" sort="Sher, Affan A" uniqKey="Sher A" first="Affan A" last="Sher">Affan A. 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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30966844" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |